Review correct procedure and precautions for the following routes of administration ear drops enteral feeding tube eye drops im subcut injections iv therapy including ivp and ivpb long acting sr xr medications medications that cause gastrointestinal irritation such as oral potassium chloride and prednisone pca pump rectal suppository. Nurses assess patients and their medication and use knowledge and clinical reasoning to administer medication safely results indicated nurses use of clinical reasoning to maintain safe medication administration was inadequately articulated in 10 of 11 studies reviewed conclusion nurses are primarily responsible for safe medication administration nurses draw from their foundational knowledge of patient conditions and organisational processes and use clinical reasoning that supports safe . Prior to the administration of medications the nurse must check and validate the medication order and also apply their critical thinking skills to the ordered medication and the status and condition of the client in respect to the contraindications pertinent lab results pertinent data like vital signs client allergies and potential interactions of the medication that is to be given. Nurses should review medication that requires therapeutic lab monitoring carefully by following their agencys guidelines for example coumadin and heparin drip furthermore nurses have to educate patients about all new medication the indication side effects and adverse reactions medication administration steps